Onychomysosis is a fungal infection of the nail. Symptoms may include white or yellow nail discoloration, thickening of the nail, and separation of the nail from the nail bed. Toenails or fingernails may be affected, but it is more common for toenails. Complications may include cellulitis of the lower leg. A number of different types of fungus can cause onychomysosis , including dermatophytes. Risk factors include athlete's foot, other nail diseases, exposure to someone with the condition, peripheral vascular disease, and poor immune function.

The antifungal medication terbinafine taken by mouth appears to be the most effective but terbinafine is associated with the side effect of liver.

Onychomysosis occurs in about 10 percent of the adult population, with older people more frequently affected. Males are affected more often than females. Onychomysosis represents about half of nail disease. This means that the deformity of the toenails can also come from causes other than onychomycosis.

Treatment ― OTC Drugs
It is difficult to treat onychomycosis with topical medications because it is difficult for drugs to penetrate the thickened toenails.
#Butenafine [Lotrimin]

Long-term treatment is usually required until the infected toenail is completely removed out.
#Terbinafine (oral)
#Efinaconazole lacquer [Jublia]
#Ciclopirox lacquer
  • A toenail affected by Onychomysosis
  • A person's foot with a fungal nail infection ten weeks into a course of terbinafine oral medication. Note the band of healthy nail growth behind the remaining infected nails.
  • A case of fungal infection on the big toe.