Intraepithelial carcinoma (Bowen disease)
Intraepithelial carcinoma (Bowen disease) shows atypical squamous cells proliferate through the whole thickness of the epidermis. The entire tumor is confined to the epidermis and does not invade into the dermis. This disease is technically classified as cancerous, but non-invasive unlike common cancers. (i.e. it is a cancer with a good prognosis.)

It usually appears as a erythematous, scaly or crusty area anywhere on the body. The most common location is lower legs.

It is curable by various treatment options such as cryotherapy, curettage, cautery, photodynamic therapy, or excision of the lesion.

Diagnosis and Treatment
#Skin biopsy
#Mohs surgery
#Photodynamic therapy
  • Typical case ― Intraepithelial carcinoma (Bowen disease) may be misdiagnosed as a long-lasting, non-itchy eczema.
  • Cutaneous horn ― Unlike warts, it presents as a hard nodule, and a biopsy is necessary to exclude malignancy.
  • If a wound persists for a prolonged period, skin cancer should be considered.
  • Intraepithelial carcinoma (Bowen disease) ― Typical case
  • In this case, Irritated seborrheic keratosismay also be considered as a potential differential diagnosis.
  • It is often mistaken for an allergic disorder (for example, nummular eczema ).
  • Intraepithelial carcinoma (Bowen disease) ― Typical case
  • Another typical case presents similar morphological features to allergic conditions.